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High blood cholesterol is a major women's health issue. One in three Americans has high cholesterol, according to the Centers for Disease Control and Prevention.
Overall, an estimated 78 million American adults (37 percent) have high low-density lipoprotein (LDL) or "bad" cholesterol. Of these, about half are taking the necessary measures to get the condition under control. It is important to keep LDL cholesterol in a healthy range because high LDL cholesterol levels are a contributing factor to heart disease, which develops over years.
But don't fool yourself into thinking that high blood cholesterol is a problem only for middle-aged or elderly men and women. High cholesterol is a problem for some children and teenagers, too. According to the American Heart Association, 7 percent of adolescents have high cholesterol.
The guidelines regarding the diagnosis and treatment of high cholesterol changed in 2013 and again in 2018 when the American College of Cardiology (ACC) and the American Heart Association (AHA) released new cholesterol guidelines.
The biggest difference in 2013 was that the new guidelines no longer contained "treatment targets"—cholesterol levels at which health care professionals are instructed to start treatment. The ACC/AHA guidelines also endorsed a specific risk assessment tool, which assesses your 10-year risk of heart disease or stroke.
The 2018 ACC/AHA Guidelines on the Management of Blood Cholesterol allow for more personalized care for patients, including more detailed risk assessments and new cholesterol-lowering drug options for people at the highest risk for heart disease.
Also, in addition to traditional risk factors for high cholesterol such as smoking, high blood pressure and high blood sugar, the 2018 guidelines add factors such as certain health conditions including metabolic syndrome, kidney disease, premature menopause, chronic inflammatory diseases and high lipid biomarkers. They also look at family history and ethnicity when determining risk and options for treatment.
The 2018 guidelines recommend that health care providers use coronary artery calcium scores as a secondary tool when deciding whether to prescribe statin drugs.
In addition, the 2018 ACC/AHA guidelines recommend the following:
Going By the Numbers
Despite new ACC/AHA guidelines, some practitioners still prefer to follow the previous guidelines from the National Cholesterol Education Program (NCEP), a division of the National Heart, Lung and Blood Institute (NHLBI). The NHLBI/NCEP guidelines provide specific numbers for cholesterol goals and beginning treatment. To that end, here are the older guidelines:
Total blood cholesterol levels (calculated by taking your LDL cholesterol plus your high-density lipoprotein [HDL] cholesterol plus 20 percent of your triglycerides)
Normal: less than 200 mg/dL
Borderline high: 200 to 239 mg/dL
High: 240 mg/dL or above
HDL blood cholesterol levels
Optimal: above 60 mg/dL. Levels above 60 mg/dL are considered especially beneficial and can offset risk factors for heart disease, according to AHA. The higher the level, the healthier it is.
Average: 50 to 60 mg/dL for women; 40 to 50 mg/dL for men
Low: less than 50 mg/dL for women; less than 40 mg/dL for men. Below these levels is considered a major risk factor for heart disease.
Non-HDL cholesterol levels
This is calculated by subtracting HDL cholesterol from total cholesterol.
Optimal: Less than 130 mg/dL. Higher numbers indicate a higher risk of heart disease.
Triglyceride levels
Normal: less than 150 mg/dL
Mildly increased: 150 to 499 mg/dL
Moderately increased: 500 to 886 mg/dL
Very high: Greater than 886 mg/dL
Your Cholesterol Glossary—Terms to Know
While high levels of cholesterol—a waxy, fat-like substance—are dangerous, our bodies do need some cholesterol. Cholesterol belongs to a family of chemicals called lipids, which also includes fat and triglycerides. Cholesterol is found in cells or membranes throughout the body and is used to produce hormones, vitamin D and the bile acids that help digest fat. The body is able to meet all these needs by producing cholesterol in the liver.
Saturated fats, found primarily in whole-milk dairy products and meats, and trans fats from foods like coconut oil, cocoa butter, palm kernel oil, palm oil and partially hydrogenated oils—sometimes found in processed foods—raise blood levels of cholesterol. Over the years, cholesterol and fat in the blood are deposited in the inner walls of the arteries that supply blood to the heart, called the coronary arteries. These deposits make the arteries narrower, a condition known as atherosclerosis. It is a major cause of coronary heart disease (CHD).
Dietary cholesterol, such as is found in eggs, dairy products and some other foods, may also raise cholesterol in the blood slightly, but newer studies find that consumption of dietary cholesterol is unlikely to substantially increase risk of coronary heart disease or stroke among healthy men and women.
If the coronary arteries become narrowed or blocked, then oxygen- and nutrient-supplying blood can't reach the heart. The result is coronary heart disease (CHD) or a heart attack. The part of the heart deprived of oxygen dies.
Types of blood cholesterol
Cholesterol travels in the blood in packages called lipoproteins, which consist of lipids (fats) and protein. Cholesterol packaged in low-density lipoprotein (LDL) is often called "bad" cholesterol because too much LDL in the blood can lead to cholesterol buildup and blockage in the arteries. LDL carries most of the cholesterol in the blood.
Another type of cholesterol package is high-density lipoprotein (HDL), often called "good" cholesterol. HDL helps transport cholesterol from other parts of the body to the liver, which helps remove it from the body, preventing it from piling up in the arteries.
A third type of lipoprotein is very low density (vLDL). This package transports triglycerides in the blood; high levels of vLDL and triglycerides have also been linked to an increased risk of heart disease. However, vLDL is not measured routinely.
You can think of all bad cholesterol put together as "non-HDL cholesterol." Non-HDL cholesterol is a good predictor of cardiovascular disease risk, and it is a better predictor of risk than LDL cholesterol in women, as well as in people with type 2 diabetes
The American Heart Association (AHA) recommends checking cholesterol levels once between the ages of 9 and 11 years and again between the ages of 17 and 21 years for children and young adults without other risk factors or a family history of early heart disease. After age 20, your health care provider should recheck your cholesterol and other risk factors every four to six years as long as your risk remains low.
Medicare beneficiaries can now get a free cardiovascular screening test for cholesterol, triglycerides and lipid levels. Ask your health care professional about this benefit.
Additionally, children ages 2 or older with a family history of premature heart disease, at least one parent with high blood cholesterol or a condition commonly associated with increased risk of coronary heart disease, such as obesity or hypertension, should have their cholesterol levels tested.
Blood cholesterol levels are measured with a small blood sample. You should have a complete lipoprotein panel, which measures total cholesterol (LDL + HDL), LDL (bad cholesterol), HDL (good cholesterol) and triglyceride levels. Ideally, it should be a fasting panel, completed after you've fasted for nine to 12 hours.
Your health care professional may also order "expanded" cholesterol testing. These tests identify the levels of certain types of LDL cholesterol, including the number of particles and their size, providing a more accurate reading of your overall risk of cardiovascular disease.
Additionally, other markers indirectly related to lipids but associated with cardiovascular risk, like homocysteine and C-reactive protein, may be measured.
It is possible to have a standard lipid profile with all your numbers in the target range, but still have an LDL particle number or homocysteine level that increases your risk for cardiovascular disease. Such expanded testing may help your health care provider better target your therapy to reduce your individual risk.
Therapeutic lifestyle changes (TLC) are generally considered the first line of treatment for high LDL cholesterol. They focus on limiting saturated fat and increasing soluble fiber in the diet, managing weight and increasing physical activity.
Guidelines issued by the ACC/AHA emphasize intensified use of nutrition, physical activity and weight control in the treatment of elevated blood cholesterol—specifically LDL cholesterol. The 2018 guidelines put an even greater emphasis on lifestyle factors, particularly in adults ages 20 to 39, who have more years to adopt healthy habits and prevent cardiovascular heart disease.
The guidelines emphasize creating a healthy balance between the calories you take in with food and the calories you burn with physical activity. If you are trying to lose weight, aim to burn more calories than you take in. They recommend getting at least 30 minutes of moderate physical activity on most—preferably all—days of the week. For those with high blood pressure or cholesterol, the AHA recommends 40 minutes of moderate to vigorous activity, three to four times a week.
In terms of diet, the guidelines suggest:
For more information on lifestyle changes, check out the AHA's Diet and Lifestyle Recommendations.
In children with elevated cholesterol, the AHA recommends the first line of treatment be lifestyle changes to encourage healthier eating and more physical activity.
Soluble fiber. According to the AHA, you should aim for 25 grams of soluble fiber per day. Good sources of soluble fiber include oats and oat bran, barley, beans, eggplant and okra.
Nuts. Nuts contain a lot of calories, but a small handful a day of any kind of nut can be a heart-healthy snack.
Lean protein. Aim for about 646 grams of protein a day. Opt for low-fat sources of protein, such as lean meats, low-fat dairy products, soy and legumes. You can find soy in soybeans (edamame), tofu, soy milk, soy bars, soy burgers, dried soy protein and more. Fish is another good protein source for heart health; try for two servings per week.
Comprehensive lifestyle changes—low-fat vegetarian diet, stopping smoking, stress management training and moderate exercise—have even been shown to decrease coronary atherosclerosis. Your health care provider will likely recommend lifestyle changes as a first step in treating high cholesterol.
How Treatment Is Determined
If you have high cholesterol, you and your health care professional will determine the type of treatment that is most appropriate for you and your lifestyle. There are several major risk factors that affect your LDL cholesterol goal and will be considered when recommending a treatment plan. These are:
The ACC/AHA guidelines include a risk assessment tool to help you determine your 10-year risk of having a heart attack or dying from heart disease. The tool assigns risk values based on age, total cholesterol levels, HDL cholesterol levels, blood pressure level and diabetes and smoking status. Click here to access the risk calculator.
If lifestyle changes alone don't improve your cholesterol levels, your health care provider may recommend drug treatment. When to begin drug therapy typically depends on your risk factors. Several classes of safe, effective medications for reducing cholesterol levels are available. You may have to be proactive in getting your health care professional to consider drug therapy.
Children over age 10 whose LDL cholesterol remains high even after they've changed their dietary habits may benefit from cholesterol-lowering medication.
Medication Options for Treating High Cholesterol
There are several medications that reduce cholesterol levels. Before taking these or any other medications, talk to your health care professional about other conditions you have and medications you are taking, including birth control pills (statins, for example, can raise blood levels of birth control hormones) and over-the-counter medications, including vitamins and nutritional supplements.
Statins. Many statin drugs are available in the United States: atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev), pravastatin (Pravachol), pitavastatin (Livalo), simvastatin (Zocor) and rosuvastatin (Crestor). These highly effective drugs help reduce cardiovascular disease risk. They also provide the added benefits of increasing HDL cholesterol somewhat and reducing triglyceride levels.
Statins are also found in the combination medications Advicor (lovastatin + niacin), Caduet (atorvastatin + amlodipine) and Vytorin (simvastatin + ezetimibe).
Statins work by inhibiting an enzyme called HMG-CoA reductase, which controls the body's cholesterol production rate. They ramp down production of cholesterol and boost the liver's ability to remove LDL cholesterol from the blood. In several large clinical trials, they have proven their merit not only in lowering cholesterol levels, but also in achieving the ultimate goal: reducing heart attacks and deaths related to heart disease.
According to the ACC/AHA guidelines, there are four groups that benefit from taking a statin to lower their blood cholesterol. These groups are:
It takes about four to six weeks of taking a statin to achieve its full effect. After six to eight weeks, your health care professional will probably check your LDL cholesterol and perhaps adjust your medication.
According to the U.S. Food and Drug Administration, all statin drugs have been associated with reports of a rare and potentially fatal muscle condition called rhabdomyolysis, which causes muscle cells to breakdown and enter the bloodstream.
A much more common side effect is benign muscle pain, which sometimes responds to supplemental coenzyme Q10.
The risk of rhabdomyolysis increases with higher doses of statins and when statins are used in combination with certain drugs, such as the fibrate gemfibozil (Lopid), and cyclosporine (Restasis), a drug used to suppress immunity in people who undergo organ transplants and for the treatment of rheumatoid arthritis.
The most common side effects associated with statins are upset stomach, gas, constipation, abdominal pain or cramps and muscle pain. The effects are usually mild to moderate and fade as your body adjusts to the drug. However, if you experience brown urine or muscle soreness, pain or weakness—possible symptoms of rhabdomyolysis—contact your health care professional immediately.
Bile acid sequestrants (resins). The main bile acid resins prescribed in the United States are cholestyramine (Questran, Prevalite), colestipol (Colestid) and colesevelam (WelChol). These drugs work by binding with bile acids in the intestines that contain cholesterol. The cholesterol is then eliminated in the stool. A bile acid sequestrant may be prescribed in combination with another drug if you have high triglycerides or a history of severe constipation.
Bile acid sequestrants come in powders that are mixed with water or fruit juice and usually taken once or twice a day with meals. They are also available in pill form. They should be taken with plenty of water to avoid gastrointestinal side effects, such as constipation, bloating, nausea and gas.
If you take bile acid sequestrants, you should take any other medications at least one hour before or four to six hours after taking a bile acid resin because the bile acids can interfere with the absorption of other medications.
Niacin. This compound is more commonly known as nicotinic acid, a water-soluble B vitamin. Unfortunately, you can't lower your cholesterol by taking a vitamin supplement —to have such an effect it must be taken in doses well above the daily vitamin requirement. Although nicotinic acid is inexpensive and available over the counter, you should only take it under the direction of a health care professional.
Niacin appears to have stronger effects on HDL cholesterol and triglycerides than it does on LDL cholesterol. It comes in capsule and tablet forms, both regular and time released.
Niacin also widens blood vessels, making flushing and hot flashes frequent side effects. These side effects may be reduced by taking the drug with meals or by taking aspirin or a similar medication with nicotinic acid. The extended release form, available by prescription as Niaspan, results in less flushing and liver toxicity than the immediate or sustained release forms.
Nicotinic acid can also intensify the effect of high blood pressure medication and produce various gastrointestinal problems—nausea, indigestion, gas, vomiting, diarrhea and activation of peptic ulcers. Serious side effects include liver problems, gout and high blood sugar, with risk rising in tandem with the dose.
This drug may not be prescribed if you have diabetes because it can raise blood sugar slightly.
Fibrates. These drugs reduce triglycerides and usually raise HDL cholesterol. Fibrates are not recommended as the sole drug therapy for women with heart disease if the primary goal is reducing LDL cholesterol levels. Available fibrates are fenofibrate (Tricor, Antara, Lofibra and Triglide), clofibrate (Atromid-S) and gemfibrozil (Lopid).
Side effects are rare, with gastrointestinal problems the most common. Fibrates may also increase the risk of cholesterol gallstones and can boost the effects of blood thinners—a possibility your health care professional should watch for. Fibrates may also increase the risk of rhabdomyolysis when used in combination with statins.
Newer drugs. A relatively new class of drugs lowers cholesterol by preventing it from being absorbed in the intestine. More specifically, one approved medication in this class—ezetimibe (Zetia)—acts in the small intestine to prevent cholesterol absorption so less cholesterol reaches the liver and more is cleared from the blood. Studies find it lowers LDL cholesterol, but there is no evidence yet that it reduces heart attack risk. Another class of non-statin drugs—PCSK9 inhibitors—also shows promise in the treatment of high cholesterol.
Combination drug therapy. If you haven't achieved your target LDL cholesterol level after a few months on a single medication, your health care professional may recommend adding another. Various combinations have been shown to be effective and safe. Lower doses of each individual drug can reduce the risk of side effects.
Update on Postmenopausal Hormone Therapy for Treating Elevated Cholesterol
Postmenopausal hormone therapy once was considered a medical option for treating elevated cholesterol in postmenopausal women because research suggested it might prevent the development of heart disease—the end result of high cholesterol levels for a long time.
Most medical professionals now advise against using menopausal hormone therapy to prevent heart disease. Studies to date have not shown that hormone therapy reduces the risk for major coronary events or deaths among postmenopausal women, particularly when compared to statins.
There are things you can do to try to keep your cholesterol levels within healthy ranges. In addition to getting your cholesterol screened regularly (every four to six years for individuals with no heart disease risk factors), take these steps:
You might think the key to lowering your blood cholesterol levels is to zero in on the amount of cholesterol in foods. But such an approach addresses only part of the problem—and the lesser part at that. Reducing your cholesterol intake does indeed lower your risk of heart disease, but it has less impact on blood cholesterol levels than cutting back on saturated fat.
Saturated fat increases your blood cholesterol level more than anything else in your diet. Saturated fat is found mainly in food that comes from animals, including whole-milk dairy products such as butter, cheese, milk, cream and ice cream, as well as the fat in meat and poultry skin.
A few vegetable fats—coconut oil, cocoa butter, palm kernel oil and palm oil—are also high in saturated fat. These fats may be found in cookies, crackers, coffee creamers, whipped toppings and snack foods, which may also contain trans fatty acids, another form of fat that acts like saturated fat in the body. It is important to read food labels, which detail total fat, saturated and trans fat levels. Research is continuing to determine which of these fats are harmful; not all saturated fatty acids cause the same effects.
Polyunsaturated fats, such as safflower and corn oil, and monounsaturated fats, such as olive and canola oil, may lower LDL cholesterol levels slightly and raise HDL cholesterol levels. However, don't try to boost your intake of these fats. Instead, concentrate on cutting back fat from all sources with an eye toward using these "healthier" fats in place of saturated fats.
Omega-3 fatty acids, which are found in oily fish such as salmon and soybean and canola oil, appear to lower blood levels of triglycerides. You may want to add fish to your diet at least twice a week and choose these oils over others. Oily fish such as salmon, mackerel, albacore tuna, herring, lake trout and sardines are highest in heart-healthy omega-3s.
Psyllium, a fiber supplement, also provides cholesterol-lowering benefits when taken in conjunction with a low-fat, low-cholesterol diet. Studies have shown psyllium can lower LDL cholesterol levels, thus reducing risk of cardiovascular disease. When taken in combination with cholesterol-lowering drugs, psyllium provides added heart-healthy benefits.
If you don't have high cholesterol or heart disease, you're probably already on the right track when it comes to lifestyle. Be sure to stick with a program that keeps saturated fats to no more than 6 percent of daily calories. You should also engage in regular physical activity (at least 30 minutes a day, most days of the week; every day if possible) to keep your weight in check and possibly lower high cholesterol levels. For those with high blood pressure or cholesterol, the AHA recommends 40 minutes of moderate to vigorous activity, three to four times a week.
If your cholesterol is elevated but you don't have heart disease, develop an action plan in consultation with a health care professional.
Review the following Questions to Ask about cholesterol so you're prepared to discuss this important health issue with your health care professional.
Cholesterol is a waxy, fat-like substance found in whole-milk dairy products, eggs, animal fats and meat. It belongs to a family of chemicals called lipids, which also includes fat and triglycerides. It is found in cell walls or membranes throughout the human body and is used to produce hormones, vitamin D and the bile acids that aid the digestion of fat. Your body is able to meet all these needs by producing cholesterol in the liver.
For information and support on Cholesterol, please see the recommended organizations, books and Spanish-language resources listed below.
American College of Cardiology (ACC)
Website: https://www.acc.org
Address: Heart House
2400 N Street, NW
Washington, DC 20037
Hotline: 1-800-253-4636
Phone: 202-375-6000
Email: resource@acc.org
American Heart Association (AHA)
Website: https://www.americanheart.org
Address: 7272 Greenville Avenue
Dallas, TX 75231
Hotline: 1-800-AHA-USA-1 (1-800-242-8721)
Email: Review.personal.info@heart.org
National Heart, Lung, and Blood Institute (NHLBI) - NHLBI Health Information Center
Website: https://www.nhlbi.nih.gov
Address: Attention: Website
P.O. Box 30105
Bethesda, MD 20824
Phone: 301-592-8573
Email: nhlbiinfo@nhlbi.nih.gov
WomenHeart: National Coalition for Women with Heart Disease
Website: https://www.womenheart.org
Address: 818 18th Street, NW, Suite 930
Washington, DC 20006
Hotline: 1-877-771-0030
Phone: 202-728-7199
Email: mail@womenheart.org
Women's Health Initiative (WHI)
Website: https://www.whi.org
Address:Clinical Coordinating Center
Fred Hutchinson Cancer Research Center
1100 Fairview Ave N, M3-A410
PO Box 19024
Seattle, WA 98109-1024
Phone: 800-218-8415
Email: nihinfo@od31tm1.od.nih.gov
Women's Heart Foundation
Website: https://www.womensheart.org
Address: P.O. Box 7827
West Trenton, NJ 08628
Phone: 609-771-9600
Books
American Heart Association 365 Ways to Get Out the Fat: A Tip a Day to Trim the Fat Away
by American Heart Association
Good Cholesterol Bad Cholesterol
by Eli M. Roth M.D., Sandra Streicher-Lankin
Spanish-language resources
Family Doctor
American Academy of Family Physicians
Website: https://familydoctor.org/online/famdoces/home/common/heartdisease/risk/029.html
HealthyWomen content is for informational purposes only. Please consult your healthcare provider for medical advice, diagnosis or treatment.